AUTHOR: Biomed Mom TITLE: Epinephrine and arachidonic acid (EFA) DATE: 6/01/2007 05:08:00 PM ----- BODY:

Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes

I. N. T. de Gomez Dumm^{1, 2}, M. J. T. de Alaniz^{1, 2} and R. R. Brenner^{1, 2}

(1)	Instituto de Fisología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina

(2)	Present address: Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina

Received: 13 May 1980

Abstract The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-¹⁴C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP.

Labels: EFAs, epinephrine

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Adopt Biomed

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Friday, June 1, 2007

Epinephrine and arachidonic acid (EFA)

Effect of epinephrine and dibutyryl cyclic AMP on Δ5-desaturation activity of rat liver microsomes

I. N. T. de Gomez Dumm^{1, 2}, M. J. T. de Alaniz^{1, 2} and R. R. Brenner^{1, 2}

(1)	Instituto de Fisología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina

(2)	Present address: Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina

Received: 13 May 1980

Abstract The effect of epinephrine and dibutyryl cyclic AMP on the oxidative desaturation of [1-¹⁴C]-eicosatrienoic acid to arachidonic acid of rat liver microsomes has been studied. Epinephrine, at a dose of 1 mg/kg/body weight, produced a significant decrease on Δ5-desaturation activity 3 hr after the injection. This effect was maintained up to 12 hr and reached the control values 48 hr after the hormone administration. Dibutyryl cyclic AMP treatment for 24 hr (5 mg/8 hr/100 g body weight) also produced a significant decrease of the conversion of eicosatrienoic acid to arachidonic acid in rat liver microsomes. The effect of epinephrine on Δ5-desaturation activity was postulated to be evoked through an increase of the intracellular concentration of cyclic AMP.

Labels: EFAs, epinephrine

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