Leaky Gut Syndrome - also known as Intestinal Permeability

What is Leaky Gut Syndrome? Leaky Gut Syndrome (intestinal permeability) is not a disease but rather an intestinal dysfunction that underlies many different illnesses and symptoms. However, Leaky gut syndrome is actually poorly recognized but yet an extremely common problem. What causes Leaky Gut Syndrome? Leaky gut syndrome results in an increase in the so-called permeability of the mucosal intestinal lining to luminal macro molecules. In other words, large spaces develop between the cells of the gut wall and this allows bacteria, toxins and food to leak in. What happens next with Leaky Gut Syndrome? Once the lining of the digestive tract becomes inflamed or damaged it disrupts the way the digestive system functions. The spaces that open up allow large food antigens to be absorbed into the body, which are regarded as 'foreign' to the body's defense system. This results in the production of antibodies against what was once harmless and innocuous foods. This is how food allergies are created as well as new symptoms with target organs. e.g. arthritis and fibromyalgia. Symptoms of the Inflamed Gut associated with Leaky Gut Syndrome * It does not absorb nutrients and foods properly so it may result in fatigue and bloating. * When the detoxification pathways that line the gut are compromised, chemical sensitivity may also occur. * The leaking of toxins also burdens the liver so that the body is less able to handle everyday chemicals. * Carrier proteins are also damaged so nutrient deficiencies occur which cause a variety of symptoms: o Magnesium deficiency causes muscle spasms and fibromyalgia o Copper deficiency leads to high cholesterol and Osteoarthritis o Zinc deficiency leads to malabsorption which causes hair loss and some eye disorders (macular degeneration) Inflamed Gut Lining because of Leaky Gut Syndrome When the gut lining is inflamed the protective coating of lgA (immunoglobulin A) is negatively affected. The body is unable to ward off bacteria, viruses and parasites as well as fungus and yeasts like Candida. These pathogenic bad organisms then pass from the gut cavity into the bloodstream and set up infection anywhere else in the body. Formation of Antibodies with Leaky Gut Syndrome Formation of antibodies may occur. They leak across and look similar to antigens on our own tissues. So when an antibody is made to attack it, it also attacks the tissue. This is possibly how auto-immune and chronic disease like Crohn's Disease, Rheumatoid arthritis, Lupus, Multiple Sclerosis, and Thyroiditis start. Formation of Toxins with Leaky Gut Syndrome Together these conditions encourage the formation of toxins. These toxins can also cause leaks. When food particles escape through the leaks into the blood stream, the immune system senses them as a threat (an antigen), and results in food sensitivities. Avoid Unhealthy Food if you have Leaky Gut Syndrome Poor food choices not only cause Leaky Gut Syndrome but may lead to food sensitivities as well. Processed foods are low in nutrients and fiber and often contain lots of food additives, unhealthy fats and sugar. This creates an alkaline intestinal pH and a slow waste transit time. Leaky Gut Syndrome may cause confusion, memory loss, and 'brain fog' In addition to the creation of food allergies, the bloodstream is flooded by bacteria, fungi and parasites that, in the healthy state, would not be able to penetrate the protective barrier of the gut. These microbes and their toxins, if present in large enough amounts, can overwhelm the liver's ability to detoxify. This results in symptoms such as confusion, memory loss, and 'brain fog'. The following may lead to Leaky Gut Syndrome (Intestinal Permeability): * Antibiotics - because they lead to the overgrowth of abnormal flora in the gastrointestinal tract (bacteria, parasites, candida, fungi) * Alcohol and caffeine (strong gut irritants) * Foods and beverages contaminated by parasites like Giardia lamblia, cryptosporidium, blastocystis hominis and others * Foods and beverages contaminated by bacteria like helicobacter pylori, klebsiella, citrobacter, pseudomonas and others * Chemicals in fermented and processed food (dyes, preservatives, peroxidized fats) * Enzyme deficiencies (e.g. celiac disease, lactase deficiency causing lactose intolerance) * NSAIDS (non-steroidal anti-inflammatory drugs) like ASA, ibuprofen, indomethacin, etc. * Prescription corticosteroids (e.g. prednisone, hydrocortisone, DepoMedrol, etc.) * High refined carbohydrate diet (e.g. candy bars, cookies, cake, soft drinks, white bread) * Prescription hormones like the birth control pill * Mold and fungal mycotoxins in stored grains, fruit and refined carbohydrates * Dysbiosis and gastrointestinal Disease * Chemo-therapy and radiation therapy causing immune overload Suggestions for Leaky Gut Syndrome Great Smokies Intestinal Permeability Test will assist in making an accurate evaluation of leaky gut syndrome. Microbiology evaluation will test for overgrowth of fungus, bacteria and parasites. Digestive aids like probiotics, digestive enzymes, natural herbal anti inflammatories and anti candida supplements assist in restoring the integrity of the mucosal lining of the digestive tract. Read more on Leaky Gut Syndrome (Intestinal Permeability) here.

Bad brain chemistry triggers violence

Behavior - vitamin and nutrient therapy Acts of violence in the workplace or schools often are not as random as they appear to outsiders. Parents of violent children have been telling doctors and educators for years that their kids were born with unique, disruptive, angry, defiant personalities. William J. Walsh, a senior scientist at Health Research Institute and Pfeifer Treatment Center, Naperville, Ill., backs them after 25 years of research. A study of 24 pairs of brothers, one average and one violent, was conducted by Walsh. The results, replicated in three blind, controlled experiments, showed two distinctive patterns in the brain chemistry of violent individuals not found in their siblings. The first included an elevated copper/zinc ratio; depressed sodium, potassium, and manganese; and abnormal calcium, magnesium, and blood histamines. The other revealed very depressed copper; very elevated sodium and potassium; elevated blood histamines, kryptopyrroles, lead cadmium, iron, calcium, and magnesium; and depressed zinc and manganese. How did this translate to behavior? Those having Type 1 levels exhibited Jekyll-Hyde behavior with episodic violence, poor stress control, and genuine remorse, often accompanied by acne, allergies, and academic underachievement. Type 2s were assaultive without remorse; pathological liars who had a fascination with fire; cruel to people and animals; and often had sleep disorders. The researchers later identified two additional distinctive, less-violent behavior types: nonassaultive delinquents who were impulsive, irritable, underweight underachievers in school, and nonassaultive individuals who had sugar craving, drowsiness, and depression. "The brain is a chemical factory that produces neurotransmitters such as serotonin, dopamine, norepinephrine, and other brain chemicals 24 hours a day. The only raw materials for these syntheses are nutrients: amino acids, vitamins, minerals, etc.," Walsh notes. "Most neurotransmitter imbalances appear genetic in nature and involve abnormal metabolism, absorption, and/or storage of food nutrients by the body. However, an individual's biochemistry may change at any time after birth as a result of food allergies, puberty, aging, stress, or trauma. The Pfeiffer Center's treatment consists of nutrient therapy--utilizing vitamins and minerals along with dietary adjustments--to correct brain chemistry imbalances. "Nutrient therapy can be very potent and, unlike most psychiatric medications, does not involve side effects since no molecules foreign to the body are used," he explains. Some violent offenders are psychiatric patients who have stopped taking medications due to the debilitating side effects. Pfeiffer doctors keep patients on prescription medications while balancing brain chemistry. In some cases, they work with the patient's physician in the effort to eliminate or gradually reduce medications and minimize side effects. COPYRIGHT 2002 Society for the Advancement of Education COPYRIGHT 2002 Gale Group

Heating Milk reduces its allergenic qualities?

Br J Nutr. 1984 Jan;51(1):29-36 Reduction in the antigenicity of whey proteins by heat treatment: a possible strategy for producing a hypoallergenic infant milk formula. * Heppell LM,* Cant AJ,* Kilshaw PJ. Residual antigenic protein in heat-denatured cow's milk whey and in two commercial infant milk formulas was determined using enzyme-linked immunosorbent assays specific for beta-lactoglobulin, alpha-lactalbumin, bovine serum albumin, bovine IgG1 and alpha-casein. This immunochemical assessment of antigenicity was related to the capacity of the preparations to sensitize immunologically when fed to guinea-pigs for 2 weeks. Antibody production was measured and the susceptibility of the animals to systemic anaphylaxis was assessed by injecting them intravenously with heated or unheated milk proteins. Whey protein that had been heated at 100 degrees or 115 degrees for 30 min was extensively denatured and, in contrast to pasteurized whey, failed to sensitize guinea-pigs for anaphylaxis. Antibody production was undetected or very low. The proteins in SMA powder and SMA Gold Cap liquid concentrate were less denatured and animals given these formulas prepared according to the maker's instructions produced relatively high levels of antibodies to beta-lactoglobulin and alpha-casein and a majority developed anaphylaxis when injected intravenously with these products. As well as failing to sensitize, whey that had received severe heat treatment did not, in most cases, elicit anaphylaxis when injected into animals that had been sensitized with unheated milk. Discrimination between antibodies of the IgG1 and IgG2 subclasses specific for beta-lactoglobulin showed that IgG1, the principal anaphylactic antibody in guinea-pigs, was preferentially depressed in animals drinking heat-denatured milk preparations. The results suggest that heat denaturation of whey protein may be a logical and simple strategy for producing a hypoallergenic baby milk. Nevertheless, the value of experiments in guinea-pigs for predicting results in man is uncertain and the proposal awaits assessment in clinical trials.

Mercury and ADD/Autism/Allergies/Immune System

Get your coffee before sitting don to read this one. It's long, but it's full of information! ~L Immune Reactive Conditions: The mercury connection to autism, schizophrenia, ADD, eczema, lupus, asthma, and allergies (snipped from larger study) Bernard Windham- Chemical Engineer The incidence of neurotoxic, allergic, and immune reactive conditions such as autism, scizophrenia, ADD, dyslexia, allergies, asthma, eczema, lupus, psoriasis, childhood diabetes, etc. have been increasing rapidly in recent years(1,2,3,5,23). A recent report by the National Research Council found that 50% of all pregnancies in the U.S. are now resulting in prenatal or postnatal mortality, significant birth defects, or otherwise chronically unhealthy babies(3). Exposure to toxic chemcials or environmental factors appear to be a factor in as much as 28 percent of the 4 million children born each year(3), with 1 in 6 having one of the neurological conditions previously listed.. According to the U.S. FDA, at least 26 million have allergies and at least 17 million have asthma. The largest increase has been in infants (1,2,,5-7,23), with an increase in autism cases to over 500,000 (1,2,23,22), an over 500% increase to a level of almost 1 per 250 infants in the last decade(2), making it the 3rd most common childhood condition, along with similar increases in ADD, and over 10 % of infants- approximately 15 million in the U.S. with such conditions or systemic eczema(1). Studies researching the reason for these rapid increases in infant reactive conditions seem to implicate earlier and higher usage of vaccines containing mercury(thimerosal) as a likely connection(2,2b,23,30,40). A recent study comparing pre- and post-vaccination mercury levels, found a significant increase in both preterm and term infants after vaccination(42), with post-vaccination mercury levels approximately 3 times higher in the preterm infants as compared with term infants. The study found mercury blood levels up to 23.6 ug/L and received an average dose of 16.7 ug/kg. Just this one vaccination gave an exposure to mercury that is many times the U.S. ATSDR adult minimum risk level(MRL) for mercury of .3/ug/kg body weight per day(41). It has been estimated that if all of the vaccines recommended by the American Assoc. of Pediatrics are given and contain thimerosal, then by age 6 months an infant would have received 187 micrograms of ethyl mercury which is more than the EPA/ATSDR health standard for organic mercury(33,41) and by age 3 the typical child has received over 235 micrograms of mercury thimerosal from vaccinations which is considerably more than Federal mercury safety guidelines (41), in addition to significant levels from other sources for many(23). Infants during this period have undeveloped blood brain barriers and much of the mercury goes to the brain, resulting in significant adverse neurological effects in those that are most susceptible(43,3). Because of the evidence the FDA has completed a study and written a letter to vaccine manufacturers asking that mercury be removed from vaccines. The updated letter stated, "The Center for Biologics Evaluation and Research (CBER) has completed its evaluation of the use of thimerosal in vaccines...Our review concluded that reducing or eliminating thimerosal from vaccines is merited(44). The letter pointed to a joint statement by the American Academy of Pediatrics and the United States Public Health Service in 1999, which "called for the removal of thimerosal from vaccines as soon as possible." Many thousands of parents have reported that their child got such conditions after vaccination, and tests have confirmed high levels of mercury in Many of those tested, along with other toxic exposures. An additional source of thimerosal to the fetus of women who are RH negative is the 30 micrograms in the RhoGAM shot they receive. Underweight infants that get the same dose of thimerosal as other infants have also been found to be at special risk. Many of those diagnosed with high mercury levels have also been found to have significant improvement after mercury detoxification(23,30,40,11,35). Thimerosal had been previously removed from similar preservative uses in eye drops and eye medications after evidence of a connection to chronic degenerative eye conditions. After over 15,000 law suits were filed in France over adverse effects of the Hepatitis B vaccine, the French Minister of Health ended the mandatory hepatitis B vaccination program for all school children. Adverse effects included neurological disorders and autoimmune disorders such as multiple sclerosis and lupus. Some hospitals in the U.S. also quit recommending certain vaccinations. Although vaccinations appear to be the largest source of mercury in infants, mercury has been found to be transmitted from the mother to the fetus through the placenta and accumulate in the fetus to higher levels than in the mother’s blood(22). Breast milk of women who have amalgam fillings or eat a lot of fish has also been found to be a significant source of mercury in infants and young children(22,45). A direct mechanism involving mercury’s inhibition of cellular enzymatic processes by binding with the hydroxyl radical(SH) in amino acids appears to be a major part of the connection to these allergic/immune reactive conditions (15-23,36,46). For example mercury has been found to strongly inhibit the activity of xanthine oxidase and dipeptyl peptidase (DPP IV) which are required in the digestion of the milk protein casein(15,16,17,19,20,22), and the same protein that is cluster differentiation antigen 26 (CD26) which helps T lymphocyte activation. CD26 or DPPIV is a cell surfact glycoprotein that is very susceptible to inactivation by mercury binding to its cysteinyl domain. Mercury and other toxic metals also inhibit binding of opioid receptor agonists to opioid receptors, while magnesium stimulates binding to opioid receptors (15). Studies involving a large sample of patients with autism, scizophrenia, or mania found that over 90 % of those tested had high levels of the milk protein beta-casomorphin-7 in their blood and urine and defective enzymatic processes for digesting milk protein(24,25,27), and similarly for the corresponding enzyme needed to digest wheat gluten(24,26).The studies found high levels of Ig A antigen specific antibodies for casein, lactalbumin and beta-lactoglovulin and IgG and IgM for casein. Beta-casomorphine-7 is a morphine like compound that results in neural dysfunction (24,25), as well as being a direct histamine releaser in humans and inducing skin reactions (14,21,25c). Similarly many also had a corresponding form of gluten protein (26). Elimination of milk and wheat products and sulfur foods from the diet has been found to improve the condition. A double blind study using a potent opiate antagonist, naltrexone(NAL), produced significant reduction in autistic symptomology among the 56% most responsive to opioid effects(28). The behavioral improvements was accompanied by alterations in the distribution of the major lymphocyte subsets, with a significant increase in the T-helper- inducers and a significant reduction of the T-cytotoxic-suppressors and a normalization of the CD4/CD8 ratio. Studies have found mercury causes increased levels of the CD8 T-cytotoxic-suppressors(29). As noted previously, such populations of patients have also been found to have high levels of mercury and to recover after mercury detox(23,11,22,30,40). As mercury levels are reduced the protein binding is reduced and improvement in the enzymatic process occurs(22,11). Additional cellular level enzymatic effects of mercury’s binding with proteins include blockage of sulfur oxidation processes and neurotransmitter amino acids which have been found to be significant factors in many autistics(18,36,46,17), plus enzymatic processes involving vitamins B6 and B12, with effects on the cytochrome-C energy processes as well. Epson salts(magnesium sulfate)baths, supplementation with the p5p form of Vit B6 and vit B12 shots are methods of dealing with these enzymatic blockages that have been found effective by those treating such conditions. Mercury has also been found to have adverse effects on cellular mineral levels of calcium, magnesium, zinc, and lithium(39,22,46). Supplementing with these minerals has also been found to be effective in the majority of cases(39) Another of the results of these toxic exposures and enzymatic blockages is the effect on the liver and disfunction of the liver detoxification processes which autistic children have been found to have (30,36,22). All of the autistic cases tested were found to have high toxic exposures/effects and liver detoxification profiles outside of normal(30). Along with these blockages of cellular enzymatic processes, mercury has been found to cause additional neurological and immune system effects in many through immune/autoimmune reactions(11,12,35). Mercury(22) as well as thimerosal (31,32) also have direct neurotoxic effects on brain nucleotid binding proteins through their effect on Ca2+ATPase and Na+/K+ATPase activity. But the effects on the neurological and immune systems of exposure to various toxic substances such as toxic metals and environmental pollutants has also been found to have additive or synergistic effects and to be a factor in increasing eczema, allergies, asthma, delayed food allergies, and sensitivity to other lesser allergens(14-22,35). Most of the children tested for toxic exposures have found high or reactive levels of other toxic metals, and organochlorine compounds (30,40,11,12,35,4). Other than the organochlorines or toxic metals which are discussed later, three common pollutants that have been documented to have effects on such conditions are traffic and industrial pollutants nitrogen oxide, power plant residual oil fly ash, and organochlorine pollutants(4). Another effect of mercury and toxic metals is a reduction in B- lymphocytes (37,38,22). One of these studies(37) dealing with autistic patients and further work with such patients has found this causes a tendency to be more seriously affected by viruses and to develop intestinal disorders including leaky gut, lymphoid modular hyperplasia, and a high incidence of parasites. Allergic contact eczema is the most frequent occupational disease(1,22), and the most common cause of contact eczema is exposure to toxic metals(1, 6- 12,22). The metals most commonly causing allergic immune reactivity are nickel, mercury, chromium, cobalt, and palladium(1,6-14,22). The highest level of sensitization is to Infants, who are most reactive to thimerosal, a form of mercury that has been used as a preservative in vaccines and eye drops(6,7). There is strong suggestive and clinical evidence for a connection between toxic metals and autism(2b,15-40).