Natural Approaches to ADHD

Nutritional Breakthroughs for ADHD by Angela Stengler, ND Could food allergies be causing your child's ADHD? After a child has been diagnosed with attention deficit disorder, many parents come to me with questions and concerns regarding their child's diagnosis and possible treatments. No one is really sure what causes hyperactivy in children, although there are plenty of culprits people point to--sugar sensitivities, environmental toxins, food allergies--but no one thing has been identified as the specific cause. Unfortunately, when a diagnosis is made, quite often the only solution provided to parents is a prescription for stimulants like Ritalin. However, drugs are not your only choice and there are natural therapies available to you that can safely and effectively treat ADHD in your child--and without any of the negative side effects caused by some drug therapies. I have outlined several below. Read them, and then consult with your pediatrician or naturopath to see which treatment would be best suited for your child. POSSIBLE CAUSES OF ADHD Food additives Over 5,000 food additives are present in the food supply, and according to Benjamin Feingold, MD, 40 to 50 percent of all hyperactive children have some sort of sensitivity to the artificial colorings, flavorings and preservatives used in many processed foods. Feingold bases his claims on 1,200 cases of learning and behavior disorders observed in childern that were linked directly to food additives. This seems to suggest that there is a direct correlation between diets high in processed foods and hyperactivity in children. How Villainous is Sugar? For some kids, sugar is a major factor in mood, behavior and attention patterns. It has been demonstrated that destructive, aggressive and restless behavior correlates directly with the amount of sugar consumed on a daily basis. Once again, diet is both the problem and the solution. Food Allergies/Sensitivities The most common food sensitivities in children are to the following foods: •sugar •cow's milk •wheat •chocolate •soy •citrus fruit •corn •peanuts Double-blind studies have shown that when children with ADHD follow a hypoallergenic diet, substantial improvement in their symptoms are demonstrated. It should be noted that food sensitivities and food allergies are not the same thing. Food allergies are present when a child exhibits severe reactions to allergens--like peanuts or albumen from eggs--present in foods. Symptoms can include, shortness of breath, breaking out in hives, vomiting or anaphylaxis, a life-threatening condition which is characterized by the swelling of the throat and tongue. Food sensitivities are exhibited when a child is given food--like dairy products in the lactose intolerant child--which he is unable to digest properly. Commonly, he will experience indigestion, gas or irritable bowels as a result of eating these foods. If you suspect a food allergy in your child, make an appointment to get him tested. Dietary Steps You Can Take 1. Add more whole foods to the diet (whole grains, legumes, vegetables, fish) while eliminating (or at least decreasing) processed foods that contain white flour, processed sugars and hydrogenated oils (i.e, chips, cookies and sodas). 2. It goes without saying that you should make it your business to read the ingredient labels on all food products you buy for your children. Many parents don't realize that much of the pre-packaged food--including supermarket multi-vitamins and the so-called "fruit" drinks--they give to their children is loaded with artificial sweeteners, preservatives, dyes and other harmful additives that could be triggering specific behavioral and health problems in their children. If the chemical ingredients outnumber organic ingredients--or if they are the first few ingredients listed--on a food label, you may want to consider buying something else. Check labels on milk, meat and eggs too because many farmers feed hormones and antibiotics to their livestock. 3. Shop for organic fruits, vegetables and meats. These are foods that have been grown according to specific agricultural practices (typcially without using chemical pesticides or fertilizers). Hit the health food store for whole grain breads and healthy snacks to give to your kids in place of the processed ones they've been eating. Not only do these foods taste great, but they are much better for your kids overall health (many are lower in fats and sugars). 4. Natural sugars like those found in fruit and fruit juices, or natural sweeteners like honey, blackstrap molasses and rice bran syrup, should replace all processed sugars in your child's diet (this includes raw or brown sugars). If your child drinks a lot of soda make the switch to 100 percent fruit juices and dilute them 50 percent with water. Instead of those sugary breakfast cerals, try feeding your kids oatmeal topped with honey and fresh fruit, or give them naturally sweetened granola or muesli. They'll have more energy between breakfast and lunch, and their teachers will love you for it. 5. Eliminate all the foods listed under Food Allergies/Sensitivies from your child's diet for four weeks and see if their behavior improves. Wheat alternatives, such as oat, kamut and spelt, are available at most health food stores as are milk alternatives like calcium-enriched rice or oat milk. Both taste great and come in flavors like chocolate and vanilla. Yogurt made from goat's milk should be substituted for products made from cow's milk (the same is true for cheeses, too). Other Potential Factors Could food allergies be causing your child's ADHD? NUTRITIONAL DEFICIENCIES & ADHD Nutritional deficiencies are a widespread cause of learning and behavior problems in children. Studies have shown increased intelligence in children who added multivitamin supplements to their daily diets. Thiamin, niacin, vitamins B6 and B12, copper, iodine, iron, magnesium, manganese, potassium and zinc are nutrients that play a vital role in proper brain and nervous system function. Many ADHD children can benefit from an extra 500 to 1,000 milligrams of calcium and magnesium in their diet. Food sources are the best means for incorporating these important nutrients into your child's diet (especially as laid out in the previous dietary steps), but if your child can't drink milk or doesn't like to eat his green leafy veggies, vitamin supplements are the next best answer. American Kids Iron Deficient Surprisingly, the most common nutrient deficiency in American children is iron deficiency (again, a direct result of a nutrionally deficient diet). Studies have linked iron deficiency with decreased attentiveness, a narrow attention span and decreased voluntary activity. These symptoms are usually reversed after supplementation. A severe deficiency in iron can lead to anemia, which in turn can lead to listlessness, tiredness and low energy levels in children--symptoms which make it difficult for children to pay attention in school. If you suspect that your child is anemic have him tested by your physician. Always have your child tested for iron deficiency before administering iron supplements. Legumes, green leafy vegetables, blackstrap molasses and lean red meats are the best sources for iron. Look for liquid iron supplements, which are easier for kids to take, and are less likely to cause constipation or stomach upset--two of the occasional side effects of iron supplementation in children. What Are Smart Fats? Current research shows a link between learning and behavioral difficulties and deficiencies in essential fatty acids (EFAs) like docosahexanoic acid (DHA), one of the most important essential fatty acids. EFAs are commonly referred to as Omega 3 and Omega 6 fats. Oils, like evening primrose oil, flaxseed oil and borage oil, are high in EFAs. DHA plays a pivotal role in brain and retina development in babies, and the richest sources of it are a mother's breast milk and fish oils. Researchers at Purdue University looked at the levels of essential fatty acids in children, especially DHA, and found that kids with ADHD tended to have significantly lower levels of essential fatty acids in their blood. Children with ADHD should be given vitamin supplements that contain a combination of essential fatty acids that includes DHA. Nursing your children for as long as possible, and--when they are older--getting them to eat deep water fish like salmon, halibut and tuna are ways to ensure they get enough essential fatty acids into their diet during the crucial developmental years (when the body is still growing and in need of quality nutrients). Phosphatidylserine Phosphatidylserine (known as PS) is a specific brain nutrient that can be supplemented to help promote proper brain and neurological function. It works to balance the cell-to-cell communication that occurs in the brain. I recommend giving PS by itself to children with ADHD or in combination with DHA or the herb ginkgo biloba (which has excellent research supporting its benefit on memory and concentration). PS appears to help improve concentration and have a calming effect on hyperactive kids. Most PS supplements are soy-based. Typical dosage for a 12-year-old would be 200 to 400 milligrams daily. Consult your naturopathic physician or nutritionist for specific dosage requirements for your child based on his age, size and weight. ENVIRONMENTAL TOXINS Heavy Metals Finally, numerous studies have found a strong relationship between childhood learning disabilities and body storage of heavy metals (lead, mercury, cadmium, copper and manganese). Heavy metals are stored in the bones and fatty tissues of the body, like the liver and the kidneys, and high levels in very young children can hinder proper development of the brain and central nervous system. Lead is the primary culprit of heavy metal toxicity in young children, especially among toddlers living in old houses where they eat the lead paint that chips off of walls and windowsills. A child who is suffering from mild lead or heavy metal poisoning may not exhibit any specific symptoms, so a hair analysis is the best screening test for heavy metal toxicity and mineral imbalances. What Can You Do? Adding calcium and magnesium supplements to your child's diet is one way to counter potential lead poisoning (in the body, lead competes with calcium. A child exposed to high levels of lead paint dust will absorb the lead and excrete the calicium). January 1999 Dr. Angela Stengler is a certified naturopathic physician based in Oceanside, California. Women's and children's health are the focus of the practice run by her and her husband, Dr. Mark Stengler. In addition to maintaining her medical practice, Dr. Stengler hosts a weekly radio show on natural medicine, and she is the author of several books on the benefits of alternative medicine, which you can find at her Web site, The Natural Physician.

Non-medical solutions for ADHD

http://www.wisechoiceeducationalservices.com/articles/article10.html By Suzanne Day Parents of children with learning or attention problems will often react negatively to the use of medications, which are recommended by the medical profession. However, what parents really need and want is guidance in their search for solutions. This article attempts only to guide parents to a better understanding of the different aspects of the biochemical components of learning difficulties and attention behavioural problems. I do not pretend to be an expert in the nutrition but an expert on the brain, which is fuelled by nutrition. Parents and professionals dealing with attention deficits in children observe the food-mood connection, which is more evident in some children than others. Behaviours are based on thoughts and memories processed in the brain. The neurons (brain cells) transmit information as electrical signals with the use of neurotransmitters. These transmissions constitute the biochemical basis for changes in behaviours. The brain, one of the most vital organs of the body, receives its nutrition directly from the blood stream. Therefore, balanced nutrients will enhance the biochemical and electrical functions of the brain, which in turn affect learning. Imbalance of nutrients, especially through a diet of junk food, snack and fast food, will have an adverse effect, aggravating or intensifing learning and behavioural problems. The efficient functioning of the brain requires at least the essential amino acids, essential fatty acids, essential monosaccharides (glyconutirents), vitamins, minerals, and water. Essential Amino Acids Proteins provide the needed amino acids to build healthy nerve cells. These nerve cells then provide new connections to increase retrieval (memory). Most children with learning and attention difficulties need to consume more proteins, rather than starch and sugar. However, Dr. Amen in his book Healing ADD, has found that children with obsessive-compulsive behaviours require a balanced diet of protein and starch. He also explains that these children may also benefit from additional specific amino acids which are precursors of the neurotransmitters that help with the neurotransmission of the electric influx into the brain. For example, tyrosine is a building block for dopamine (control of movements, pleasure centers, and motivation). Tyrosine is a non-essential amino acid which is abundant in brown rice, leafy vegetables, and milk. Tyrosine is considered a “spark protein”. This amino acid as a supplement is known as L-tyrosine, and should be taken on an empty stomach. Tryptophan and 5-HTP are essential amino acids and are building blocks for the neurotransmitter serotonin, which controls our emotions and our sleeping patterns. Tryptophan is considered a “sedative-protein”. Most vegetables and nuts contain tryptophan. GABA, still another essential neurotransmitter, is an anti-anxiety agent. GABA is formed in the body by glutamic acid that can be synthesized from other amino acids. Phenylalanine is an amino acid precursor of norepinephrine (arousal and attention) coming in the form of DLAP as a nutritional supplement. Proteins are essential because they contain the necessary amino acids to build healthy nerve cells. Whether supplemented or taken in the diet, amino acids must be present for children to be able to overcome with learning difficulties or those with behavioural issues. Essential Fatty Acids Dr. Michael Lyon has done extensive research to better understand some of the main nutritional root causes of attention difficulties. The essential fatty acids, omega-3 and omega-6, are required by every cell in the human body and especially in the brain which is 60% fat. These essential fatty acids seems to be greatly involved in the ability to stay focused and complete tasks. The most commonly available omega-3 fatty acids is known as alpha linolenic acid (ALA) and can be found in large quantity in flax seed oil. The omega-6 fatty acid is known as linoleic acid (LA) and can be found in pumkin , sunflower, or sesame seeds. We recommend that you use a coffee grinder and grind your seeds as you need them because they start loosing the value as soon as the seed is broken. Only if the right enzymes are present in the body, will these acids be converted to incorporate them in the brain and the immune system. However, too often the body is inefficient in converting them. The best sources of essential fatty acids are the fish oils: tuna, salmon, and cod. Hydrogenation and Trans-fatty Acids Dr Lyon as well as many other experts on this topic, warns about the use of hydrogenated fats and trans-fatty acids ( the margarine, shortening, and cooking oils) which contain almost no essential fatty acids. Hydrogenation, the most common way of drastically changing natural oils, heats oils at high temperatures. The heat alters the molecule structure, which in turn interferes with the biochemical processes, “clogging” our physiological systems, our brains included. Udo Erasmus explains that “the molecule has its “head on backwards.” Not only does the heated oil looses its nutrients, but a catalyst (heavy metals like aluminium) is added, leaving remnants in these oils that are eaten by people. Udo Erasmus concludes “The 60 grams (2 ounces) of margarine and shortening we consume each day contain more than twice as many “food additives” than are found in the other 2640 grams of food that men consume each day (1740grams by women).” “Leaky Gut” and Debris in the Blood Dr. Lyon states, "Optimal digestion, good nutrient absorption and a leak proof gut are essential for good health." Based on his experience, brain health and gut health are vitally linked. In his book, Is Your Child's Brain Starving, he explains that most children with attention deficit and hyperactivity present a “leaky gut”. As well, they lack friendly bacteria in the gut, and have different types of intestinal parasites. Let’s explain briefly the term “leaky gut”. Normally the lining of the small intestine protects us from undigested food getting into the blood stream. Unfortunately, due to different factors including the excessive consumption of starchy or sugary foods, which ADD children crave, the tight junctions between cells of the intestinal lining detach and gaps form between the cells. This leaky gut allows molecular debris to circulate throughout the entire body, interfering with organ functions. The brain is one of our vital organs and these irritants adversely affect it. Milk and its Molecule Modification One of the most common types of molecular debris is milk protein. Milk has always been recognized as an essential nutrient for building healthy bodies. However, new research has shown that milk can create allergies and seems to be the cause of many ear infections. What is happening? The problem is not the milk, but what happens when milk is homogenized and radiated. Homogenizing milk breaks down the fat molecules into minute particles, which can cross the gut barrier and be absorbed into the blood stream. This causes many problems including allergic reactions and ear infections. These “foreign” protein molecules weaken the immune system because the body recognizes the milk protein as an enemy. Organs, like the brain, are often attacked. Although, soya milk is often used to replace cows’ milk, it appears to be difficult to digest for some children, who lack the necessary enzymes. See the article “Why you should avoid Soy”, by Sally Fallon (www.mercola.com/article/soy/avoid_soy.) Healing the “Leaky Gut” Research has confirmed what Dr. Lyon found with ADD: behaviour problems, including attention problems, autism, and schizophrenia, are often linked to intestinal problems. Elaine Gottschall has brought relief to thousands with her research and her diet. In her book, Breaking the Vicious Cycle, she explains the importance of a healthy intestinal tract. According to her, inefficiency in digesting double sugars, disaccharides like table sugar and polysaccharides, leads to mal-absorption and inflammatory bowel disease. Her diet, the ‘Specific Carbohydrate Diet’, is based on a monosaccharide diet (one molecule of sugar) like glucose. Interestingly, neurobiologists have discovered that more than 90% of all the serotonin (a neurotransmitter) made and then stored, is in the gut. The lack of serotonin is blamed for depression, anxiety, and insomnia. Poor digestion, absorption and elimination may lead to mental, emotional and physical sickness. White Sugar and Hypoglycemia In my work with children with learning and attention problems, I regularly witness the fact that these children often crave sugar and starch (starch becomes sugar after it is metabolized.) Parents and educators often observe, that these children are hyperactive for a short period and then a few hours later, they become lethargic. A high sugar food made with white sugar like a chocolate bar, a soda pop, or candies, stimulate the pancreas to secrete insulin which triggers cells throughout the body to pull the excess glucose out of the bloodstream and store it for later use. Soon, the glucose available to the brain has dropped. Neurons, unable to store glucose, experience an energy crisis. The ability to focus and think suffers. This glucose deficiency is called hypoglycemia, and it can even lead to unconsciousness. The Very “Bad” Sugar: Aspartame Much research has been done on Aspartame, an artificial sweetener, used in such brands as Equal and Nutrasweet. It is about 200 times sweeter than the refined sugar. Dr. Mercola reports that “Aspartame complaints represent 80-85% of food complaints registered with the FDA. In 1991, the National Institutes of Health listed 167 symptoms and reasons to avoid the use of aspartame, but today it remains a multi-million dollar business. Known to erode intelligence and affect short-term memory, the components of this toxic sweetener may lead to a wide variety of ailments…” (the list is included in his article from his web site). He recommends an helpful documentary on this subject Sweet Misery: A Poisoned World. The “Good Sugars”: the Glyconutrients A team from the University of Arkansas, directed by Dr. Dykman has conducted special studies evaluating the effects of different types of sugars (glyconutrients) upon brain function. The term glyconutrient refers to sugars that are absolutely essential for proper cellular survival and function, especially for the immune system cells. Most people know about glucose (from sucrose or white sugar) and galactose (from milk). However, little is known about the other six essential sugars, which are not readily available through a regular diet and need to be metabolized. Abundant research studies have identified the eight essential sugars (monosaccharides) needed for cells to communicate. This fact is noted in the latest Harper Biochemistry Dictionary, a medical desk reference. Dr. Dykman‘s study, found that certain single-cell sugars or monosaccharides enhanced brainwave frequencies associated with attention and alertness, increased reaction time, and concentration. Studies clearly show the important benefits children receive from ingesting these eight essential sugars as a nutritional supplement. “Breakfast Eaters” have Better Attention Span than “Breakfast Skippers” There are many components in a child’s diet, which will have a direct affect on brain function, behaviour and academic performance. William Sears, M.D. and Lynda Thompson, PhD in their A.D.D. Book, consecrated one chapter to the subject of feeding a child's brain. According to them, "it is not only the type of food but when and how you eat it that affects brain function." Their studies show that breakfast eaters, especially those that eat a breakfast rich in protein and calcium, generally have higher grades. Breakfast skippers, on the other hand, are more likely to be sluggish and overeat throughout the rest of the day. This is observed in the change of the brain waves patterns of children training with neurofeedback at our office. We frequently observe an increase in the theta wave (the slow waves (corresponding to a tune-out mental set) after a child has eaten sugary cereals or worst after eating pancakes with maple syrup for breakfast! Neurofeedback uses a quantitative electroencephalogram (QEEG) (see article on neurofeedback training for attention span). Obviously, if a child has an increase in slow brain waves, he/she will be sluggish at school and this will have an adverse impact on behaviour and grades. The Need of Supplements in our Diet It is well recognized even by the American Medical Association that we now need to add to our diets vitamin and mineral supplements because of our depleted soils. Adding to the pesticides and other chemicals polluting added to our food chain, fruits and vegetables are lacking the essential nutrients, called “phytonutrients” because they are often picked before they ripen. These “phytonutrients” strengthen our immune systems and work like enzymes aiding digestion and absorption. Supplementing the diet with enzymes will often help people with learning and attention difficulties because the lack of digestion and absorption is often one of their physiological weaknesses. Heavy Metals and Brain Function Unfortunately, heavy metals like mercury, lead, and aluminum found in our drinking water, water pipes, some vaccines, some junk food, and the air we breathe (are just some of the source of heavy metals ingestion) interfere with the absorption of necessary minerals, like zinc. Research has shown that high intercellular copper levels and low zinc levels cause many children to be hyperactive. Antioxidants are essentials in neutralizing free radicals oxidative stress (like rust produced on metal ) that heavy metals create. Chelation can be used to remove heavy metals from the body, preventing any interference in vitamin and mineral absorption and allowing the body to replenish the cells with the healthy metals. Water and the brain health Drinking several glasses of water per day is essential, but few do it. Dr. F. Batmanghelidj's book, Your Body's Many Cries for Water (you are not sick, you are thirsty) will motivate its readers to drink water. Here is an excerpt from his book: "The human body is composed of 25% solid matter and 75% water. Brain tissue is said to consist of 85% water. Every function of the body is monitored and pegged to the efficient flow of water. “Water distribution” is the only way of making sure that not only an adequate amount of water, but its transported elements (hormones, chemical messengers, and nutrients) first reach the more vital organs.” With the use of the QEEG , I have regularly observed children, gaining more control over their slow brain waves, after drinking a glass of water. Water is necessary for the body, but not all water is equal. Chlorine, which is present in city tap water, will prevent the absorption of tyrosine, an important amino acid. Our water can also be contaminated with heavy metals. City tap water needs to be purified. Osmosis water filtering systems and distilled water filtering systems are not the best filtration methods for long-term consumption. Water from these types of filtration systems not only remove essential minerals, but this water will leach the body of its minerals. It is also interesting to know that the osmosis water has a “low pH” which means that the water is acidic and may interfere with the alkaline state of the body. Efficient water filtration systems are available and are able to remove harmful substances and yet retain the important minerals. Therefore, before children start consuming more water to transport nutrients to the body organs, attention needs to be paid to the type of water these children are ingesting. Genetically Engineered Food Our children’s health in the form of undiagnosed food allergies or intolerance to food (such as celiac disease) may be linked to genetically engineered food It is since 1997 that we have had a wide variety of unlabelled genetically-engineered foods enter our supermarket shelves. Genetic engineering has to do with implanting conglomerations of genes from viruses, bacteria, insects, and animals onto our fruits, grains, nuts, and vegetables. Would it be possible that one explanation of these allergies to nuts, unheard few years ago, could be linked with the modified structure of the nuts? For example, in tests conducted at the University of Nebraska and reported in the New England Journal of Medicine, researchers found that soybeans modified with genes from Brazil nuts produced proteins that resulted in extreme, potentially deadly allergic reactions in people sensitive to the nuts. The human body is amazingly designed. Scientist consider that we have approximately 70 trillions of cells in our body. These cells continually multiply and die resulting in having a brand new body every seven or eight years. The health of the body depends on the health of the cells which produce energy. This article enumerate some facts about the reasons why our brain can be weakened. The good news is that if we limit the ingestion of the “bad stuff” and feed the body with the nutrients it needs to function efficiently, the body can regenerate itself. To summarize, children and adults with behavioural, learning and attention problems Firstly, they should AVOID (as much as possible): * JUNK FOOD, snack food, and fast food * the genetically modified organisms * trans-fatty acids (hydrogenated oil), * food containing pesticides (www.ewg.org) * white sugar (pop, cereal, candy…) * white flour (pasta, pizza…) * food dyes (especially the red and yellow ones) * Aspartame (sugar substitute in candy and gum) and MSG (flavor enhancer) * caffeine and chocolate * homogenized milk and be careful with soya milk which is often difficult to digest * preservatives * carbonated drinks Secondly, they NEED: * vitamins (fruits, vegetables, whole grains) * minerals * phytochemical supplements * proteins (amino acids) * essential fatty acids * glyconutrients, eight essential monosaccharides (sugars) * drink daily more purified water (one quart of water for every fifty pounds of weight.) * probiotics, which are the good bacteria needed in the intestines * get rid of toxins through exercise and antioxidants (Vitamin C is excellent) * get rid of parasites * sleep well The intention of this article is to not create more problems, but to summarize the main nutritional issues related to learning and attention behaviours in order better understand some of the physical root problems of learning and attention behaviours. Pursue your research, and pray for wisdom that you may glean what you need to help your children and yourselves. Make the changes step by step. Ask God for wisdom to know what you cannot change and wisdom to know what you can and need to do. A professional assessment of your child’s balance of nutrients in relation to his/her learning and attention inefficiencies may helpful. If you need help in assessing the learning and attention inefficiencies of your child I would love to help you. Do not hesitate to contact us if you have any further questions or needs. “Behold, the eye of the Lord is upon them that fear him, upon them that hope in his mercy: to deliver their soul from death, and to keep them alive in famine. Our soul waiteth for the Lord: he is our help and our shield.” Psalm 33: 18-19 Resources To know more about glyconutrients (the good sugars): (phone David: 705-726-5971 or www.mannapages.com/davidday (the Canadian one)) Books Is Your Child's Brain Starving? Michael R. Lyon, M.D. Healing the Hyper Active Brain, Michael R. Lyon, M.D. (www.functionalmedecine.ca) Your Body's Many Cries for Water, F.Batmanghelidj, M.D. (www.watercure.com) The ADD Book, by William Sears, M.D. and Lynda Thompson, Ph.D. Breaking the Vicious Cycle, by . Elaine Gottschall (www.breakingtheviciouscycle.info) and (www.pecanbread.com) Fat that Heal, Fats that Kill, Udo Erasmus Miracle Sugars, Rita Elkins, M.H. The Second Brain, Your gut has a mind of its own, Michael D. Gershon, M.D. Healing ADD, Daniel G. Amen, M.D. (www.amenclinic.com) How to Survive on a Toxic Planet, Dr. Steve Nugent The Safe Shopper’s Bible. By Dr. Samuel Epstein, MD & David Steinman Nutrition and Mental Illness, by Carl C. Pfeiffer,Ph.D,M.D. Web sites: Dr Joseph Mercola (www.mercola.com) (look for the article "Why you should avoid Soy" by Sally Fallon and for the DVD "Sweet Misery: A Poisoned World") Environmental Causes of Learning Disabilities (www.chem-tox.com/pregnancy/learning_disabilities.htm) The Truth about Soy (www.soyonlineservice.co.nz) To know more about glyconutrients (the good sugars): (phone David: 705-726-5971 or www.mannapages.com/davidday (the Canadian one)) Copyright 2005 Suzanne Day, Neuropsychologist member of l’Ordre des psychologues du Québec

Gut Healing 1

HEALING A LEAKY GUT © What Doctors Don't Tell You (Volume 8, Issue 5) It's possible to cure a leaky gut with a nutrient dense diet and appropriate supplements. Many natural substances help repair the intestinal mucosal surface or support the liver when stressed by toxins. Your vitamin and mineral supplements should include all the B vitamins, vitamin A, C and E, zinc, selenium, molybdenum, manganese, and magnesium. Because of the association between increased gut permeability and pancreatic dysfunction, pancreatic enzymes may also be needed.Avoid drugs which damage the gut. Test for and get treated intestinal infection or dysfunction. If you haven't discovered all your allergies, follow a highly nutritious elimination diet, tailor made for you. The following substances can repair the gut wall: Epidermal growth factor (EGF), a polypeptide that stimulates growth and repair of epithelial tissue, is widely distributed in the body, with high concentrations detectable in saliva. Chew your food thoroughly, to increase salivary EGF. Also, purified EGF has been shown to heal ulceration of the small intestine (Lancet, 1993; 341: 843-8). Saccharomyces boulardii, a non pathogenic yeast originally isolated from the surface of lichee nuts, has been widely used in Europe to treat diarrhea. In France it is popularly called "Yeast against yeast" and is thought to help clear the skin in addition to the gut. Clinical trials have demonstrated the effectiveness of Saccharomyces boulardii in the treatment or prevention of diarrhea (Am J Gastroenterol, 1989; 84: 1285-7; Gastroenterol, 1989; 96; 981-8). Lactobacillus caseii var GG, a strain of lactobacillus isolated and purified in Finland, has been shown effective in the prevention of diarrhea and in the treatment of colitis. It also improves the gut permeability associated with rotavirus infection (Ann Med, 1990; 22: 57-9). Although the ability of other lactobacillus preparations to improve leaky gut has not been directly tested, it is suggested by the ability of live cultures of L acidophilus to diminish radiation induced diarrhea, a condition directly produced by the loss of mucosal integrity. Glutamine, the amino acid needed for the maintenance of intestinal metabolism, structure and function, has been shown to reverse all the gut abnormalities in patients fed intravenously. Glutamine also repairs gut lining damage caused by chemotherapy or radiation (Arch Surg, 1990; 125: 1040-5). Glutathione (GSH) is an important antioxidant. Lowered levels of liver glutathione is a common occurrence in leaky gut syndromes, contributing to liver dysfunction and liver necrosis among alcoholics and immune impairment in patients with AIDS. The most effective way to raise liver glutathione is to take its dietary precursors, systeine or methionine; the best supplements for leaky gut are GSH and N-acetyl cysteine. Avoid taking during treatment of parasite infection, especially with Artemisia. Take flavonoids before eating. They may block allergic reactions which increase permeability. Catechins have been used in Europe to treat gastric ulcerations; the flavonoids in milk thistle (silymarin) and in dandelion root (taraxacum) can protect the liver. Take essential fatty acids (EFAs), particularly gammalinolenic acid (GLA). In laboratory experiments, fish oil was able to prevent intestinal mucosal injury produced by methotrexate and protect the body from the toxins produced in the gut (Am J Clin Nutr, 1991; 54: 346-50). Take these in their most concentrated and physiologically active form to avoid exposure to large quantities of polyunsaturated fatty acids. If you are supplementing with dietary fibre, make sure you are taking hypoallergenic insoluble fibre and watch the amount. Too much may increase gut permeability (J Nutr, 1983; 113: 2300-7). Gamma oryzanol, derived from rice bran, has been extensively researched in Japan for its healing effects in the treatment of gastric and duodenal ulcers and potent antioxidant activity (Rep Hokaido Inst Pub Health, 1966; 16: 111).

Biochemical Individuality and Nutrition

Biochemical Individuality and Nutrition by Bill Walsh, Ph.D. Pfeiffer Treatment Center Introduction Each of us has innate biochemical factors which influence personality, behavior, mental health, immune function, allergic tendencies, etc. Scientists tell us that the number of different genetic combinations possible in a child from the same two parents exceeds 42 million. It’s interesting to note that we do not possess a combination of characteristics from our parents, but instead have a diverse collection of characteristics from many ancestors on both sides of the family. Except for identical twins, each human being has unique biochemistry resulting in quite diverse nutritional needs. Shakespeare was correct when he wrote "One man’s meat is another man’s poison." For example, some of us are genetically suited for a vegetable-based diet and others are not. Some persons can satisfy their nutritional needs by diet alone and others must have nutritional supplements to overcome genetic aberrations. Because of genetic differences in the way our bodies process foods, most of us are quite deficient in certain nutrients and overloaded in others. Even with an ideal diet, most of us have certain nutrients that are at very low levels with many times the RDA required to achieve a healthy balance. The nutrients in overload must be carefully avoided in vitamin supplements or serious health problems can develop. After studying the biochemistry of 10,000 persons, I’ve learned that the greatest mischief is usually caused by nutrients that are stored in excessive amounts, rather than those at depleted levels. The most common nutrients in overload include copper, iron, folic acid, calcium, methionine, manganese, choline, and omega-6 fatty acids. Of course, these same nutrients may be in deficiency in other persons. I am amused by supplement manufacturers who attempt to develop the ideal combination of vitamins, minerals, and amino acids for the general population. This is a bit like trying to determine the ideal shoe size for the population. The truth is that multiple vitamins and minerals are too indiscriminate, and may do as much harm as good. Each of us should ask the question, "Who am I nutritionally?" The answer to this question is important for all, but may be especially critical for persons with mental health problems. Nutrients and Mental Health As we enter the new millennium, the medical and scientific communities agree on the tremendous influence of neurotransmitters on behavior disorders, ADHD, depression, and schizophrenia. Most persons with these disorders were born with a predisposition for these problems due to genetically-aberrant levels of specific neurotransmitters. Our mental health is dependent upon having the proper amounts of these critical brain chemicals. Some psychiatrists express their scorn for nutrient therapies, claiming that they are too puny to have any real clinical potency. They often say, "You really need a drug medication to get the job done for a serious condition like depression." My favorite response begins by asking the question, "Where do our neurotransmitters come from?" The brain is a chemical factory which produces serotonin. dopamine, norepinephrine, and other brain chemicals 24 hours a day. The only raw material for these syntheses are nutrients, namely amino acids, vitamins, minerals, etc. If the brain receives improper amounts of these nutrient building blocks, we can expect serious problems with our neurotransmitters. For example, some depression patients have a genetic pyrrole disorder which renders them grossly depleted in vitamin B-6. These individuals cannot efficiently create serotonin since B-6 is an important co-factor in the last step of its synthesis. Many of these persons report benefits from Prozac, Paxil, Zoloft, or other serotonin-enhancing medications. However, similar benefits may also be achieved by simply giving these patients sufficient amounts of B-6 along with augmenting nutrients. Most neurotransmitter problems appear to be genetic in nature and involve abnormal absorption, metabolism or storage of key nutrients. As neuroscience advances, biochemical treatments to correct brain chemistry become better defined. Nutrient therapy can be very potent and does not involve side effects, since no molecules foreign to the body are needed. This therapeutic approach may eventually eliminate the need for most psychiatric medications. Biochemical Factors In Behavior Disorders, ADHD and Mental Illness The Pfeiffer Treatment Center has amassed a large database of biochemical information from more than 10,000 patients with mental health problems. Examination of this data shows that most of these persons have striking abnormalities in specific nutrients required for neurotransmitter production. The most common chemical imbalances we encounter include the following: Over-Methylation Many persons who suffer from anxiety and depression are over-methylated which results in excessive levels of dopamine, norepinephrine and serotonin. Typical symptoms include chemical and food sensitivities, underachievement, upper body pain, and an adverse reaction to serotonin-enhancing substances such as Prozac, Paxil, Zoloft, St. John’s Wort, and SAMe. They have a genetic tendency to be very depressed in folates, niacin, and Vitamin B-12, and biochemical treatment focuses on supplementation of these nutrients. These persons are also overloaded in copper and methionine and supplements of these nutrients must be strictly avoided. Under-Methylation Many patients with obsessive-compulsive tendencies, oppositional-defiant disorder, or seasonal depression are under-methylated which is associated with low serotonin levels. They generally exhibit seasonal allergies, perfectionism, competitiveness, and other distinctive symptoms and traits. They have a genetic tendency to be very depressed in calcium, magnesium, methionine, and Vitamin B-6 with excessive levels of folic acid. These under-methylated persons may benefit nicely from Paxil, Zoloft, and other serotonin-enhancing medications, although nasty side effects are common. A more natural approach is to directly correct the underlying problem using methionine, calcium, magnesium, and B-6. SAMe, St. John’s Wort, Kava Kava, and inositol are also very useful in treating these individuals. Metal-Metabolism A common problem in ADHD, behavior disorders, and hormonal depression is an genetic inability to control copper, zinc, manganese, and other trace metals in the body due to improper functioning of the metallothionine protein. These patients are often deficient in zinc, manganese, cysteine, serine, and vitamin B-6 and overloaded in copper, lead, and cadmium. They must avoid supplements and "enriched" foods containing copper. In addition we recommend they drink bottled water and limit use of swimming pools and jacuzzis treated with copper sulfate anti-algae agents. Foods to be limited due to high copper content include shellfish, chocolate, and carob. Elevated copper levels are associated with hormonal imbalances and a classic symptom is intolerance to estrogen. Biochemical treatment focuses on stimulation of metallothionein using zinc, manganese, cysteine, serine, and Vitamin B-6. Pyrrole Disorder A common feature of many behavior and emotional disorders is pyroluria, an inborn error of pyrrole chemistry which results in a dramatic deficiency of zinc, Vitamin B-6, and arachidonic acid. Common symptoms include explosive temper, emotional mood swings, poor short-term memory, and frequent infections. These patients are easily identified by their inability to tan, poor dream recall, abnormal fat distribution, and sensitivity to light and sound. The decisive laboratory test is analysis for kryptopyrroles in urine. Treatment centers on zinc and B-6 supplements together with omega-6 essential fatty acids. Glucose Dyscontrol Our database indicates a significant number of our patients have chronic low blood glucose levels. This problem doesn’t appear to be the cause of behavior disorders, depression, etc., but instead is an aggravating factor which can trigger striking symptoms. Typical symptoms include drowsiness after meals, irritability, craving for sweets, trembling, anxiety, and intermittent poor concentration and focus. Treatment includes chromium, manganese, and other glucose-stabilizing nutrients, but the primary focus of treatment is on diet. These patients benefit from six or more small meals daily with emphasis on complex carbohydrates and protein. In essence, they cannot tolerate large meals or quick sugars. Complex carbohydrates provide the necessary glucose in a slow, gradual manner and may be thought of as "time-release" sugar. Toxic Substances Occasionally we encounter a patient whose condition has resulted from a heavy-metal overload (lead, cadmium, mercury, etc.) or toxic levels of pesticides or other organic chemicals. Our database indicates that persons with a metallothionein disorder are especially sensitive to toxic metals, and that over-methylation is associated with severe chemical sensitivities. Effective treatment requires a three-part approach: (1) avoidance of additional exposures, (2) biochemical treatment to hasten the exit of the toxic from the body, and (3) correction of underlying chemical imbalances to minimize future vulnerability to the toxic. Malabsorption Although only 10% of our database case histories involve serious malabsorption, more than 90% of autistics exhibit this problem. There are three primary classes of absorption problems: (1) stomach problems, including excessive or insufficient HCl levels, (2) incomplete digestion in the small intestine, and (3) problems at the brush-border of the intestine where most nutrients are absorbed into the portal blood stream. The consequences can include nutrient deficiencies, irritation of the intestinal tract, candida, and mental health problems. Incomplete breakdown of protein and fats can adversely affect brain neurotransmission, and is associated with impulsivity and academic underachievement. Treatment depends on the type of malabsorption present and may involve adjustment of stomach HCl levels, digestive enzymes which survive stomach acid, nutrients to enhance digestion, and special diets. Essential Fatty Acids The brain is 20% fat (by dry weight) and these fatty substances fulfill very important functions. The myelin sheaths which surround our brain cells contain essential fatty acids which are directly involved in receptor formation and nerve transmission. A 1998 Symposium at the National Institute of Mental Health presented strong evidence of the important roles for omega-3 oils (especially EPA and DHA) and omega-6 oils (especially AA and DGLA) in ADHD, depression, and schizophrenia. A recent Harvard study showed EPA and DHA supplements to be more effective than psychiatric medications in combating bipolar depression. Typical American diets usually result in insufficient omega-3 and excessive omega-6, and some nutritionists routinely recommend supplements of omega-3 oils. However, biochemical individuality also exists with oils and certain persons are innately low in omega-6 oils. A review of symptoms and specialized plasma and red-cell-membrane lab tests can identify individual needs. Health Research Institute Pfeiffer Treatment Center HRI Pharmacy 4575 Weaver Parkway - Warrenville, IL 60555-4039 (630) 505-0300 - (630) 836-0667 fax Questions or Comments:info@HRIPTC.org | Home Page | Services | Pharmacy | Research | Education | Patient Info | Directions | All contents Copyright (c) 2004 Health Research Institute. All rights reserved. HRI is a Not-for-Profit 501c3.

Vitamin B6 Imbalance

Proper Name: Pyridoxine Hydrochloride Common Name: Vitamin B6 Evidence of Efficacy: statement to the effect of Vitamin B6 deficiency or imbalance plays a role in the symptoms of mood disorders. Observational and experimental studies have shown an association between vitamin B6 and aggression1, anxiety2,3,4, ADHD5,6,7,8,9,10,11,12, bipolar disorder13,14, depression15, 16 ,17 ,18 ,19 ,20 ,21 ,22 ,23 ,24 ,25 ,26, obsessive compulsive disorder27,28, premenstrual syndrome29, 30, 31, 32, 33,3 4,3 5,36 ,37, 38, ,39 ,40, 41, 42,43 ,44, 45, 46, 47, 48, 49, 50 ,5 1,52, 53,and schizophrenia54, 55, 56, 57, 58, 59,6 0,6 1,62 ,63 ,64 .65 References: 1. Noted in McLaren DS. Clinical manifestations of nutritional disorders, in ME Shils, VR Young, Eds. Modern Nutrition in Health and Disease, Seventh Edition. Philadelphia, Lea & Febiger, 1988. 2. Heseker H, Kubler W, Pudel V, Westenhoffer J. Psychological disorders as early symptoms of a mild-moderate vitamin deficiency. Ann N Y Acad Sci 669:352-7, 1992. 3. Hoes MJ et al. Hyperventilation syndrome, treatment with L-tryptophan and pyridoxine; Predictive value of xanthurenic acid excretion. J Orthomol Psychiatry 10(1):7-15, 1981. 4. Buist RA. Anxiety neurosis: The lactate connection. Int Clin Nutr Rev 5:1-4, 1985. 5. Coleman M et al. Serotonin in Down’s syndrome. Amsterdam, North Holland, 1973. 6. Kleijnen J, Knipschild P. Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans. Biol Psychiatry 29(9):931-41, 1991. 7. Haslam RH, Dalby JT. Blood serotonin levels in the attention-deficit disorder. Letter. N Engl J Med 309(31):1328-9, 1983. 8. Brenner A. The effects of megadoses of selected B complex vitamins on children with hyperkinesis: Controlled studies with long-term follow-up. J Learn Disabil 15(5):258-64, 1982. 9. Klieger JA, Altshuler CH, Krakow L, Hollister L. Abnormal pyridoxine metabolism in toxemia of pregnancy. Ann N Y Acad Sci 166:288-96, 1969. 10. Coleman M et al. A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children: A double-blind crossover comparison with methylphenidate. Biol Psychiatry 14(5):741-51, 1979. 11. Brenner A, Wapnir R. A pyridoxine-dependent behavioral disorder unmasked by Isoniazid. Am J Dis Child 132:773-6, 1978. 12. Bhagavan HN et al. The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics 55:437-41, 1975. 13. Moller SE et al. Tryptophan availability in endogenous depression – relation to efficacy of L-tryptophan treatment. Adv Biol Psychiatry 10:30-46, 1983. 14. The pharmacokinetics of oral L-tryptophan: Effects of dose and concomitant pyridoxine, allopurinol or nicotinamide administration. Adv Biol Psychiatry 10:67-81, 1983. 15. Noted in McLaren DS. Clinical manifestations of nutritional disorders, in ME Shils, VR Young, Eds. Modern Nutrition in Health and Disease, Seventh Edition. Philadelphia, Lea & Febiger, 1988. 16. Bell I et al. Complex vitamin patterns in geriatric and young adult inpatients with major depression. J Am Geriatr Soc 39:252-7, 1991. 17. Stewart TW, Harrison W, Quitkin F, et al. Low B6 levels in depressed outpatients. Biol Psychiatry 19(4):613-16, 1984. 18. Russ CS et al. Vitamin B6 status of depressed and obsessive-compulsive patients. Nutr Rep Int 27(4):867-73, 1983. 19. Carney MW, Ravindran A, Rinsler MG, et al. Thiamine, riboflavin and pyridoxine deficiency in psychiatric inpatients. Br J Psychiatry 141:271-2, 1982. 20. Carney MW, Williams DG, Sheffield BF. Thiamin and pyridoxine lack in newly-admitted psychiatric patients. Br J Psychiatry 135:249-54, 1979. 21. Nobbs B. Pyridoxal phosphate status in clinical depression. Letter. Lancet i:405, 1974. 22. Bermond P. Therapy of side effects of oral contraceptive agents with vitamin B6. Acta Vitaminol Enzymol 4(1-2):45-54, 1982. 23. Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrocholoride (vitamin B6) upon depression associated with oral contraception. Lancet ii:899-904, 1973. 24. Adams PW, Wynn V, Seed M, Folkard J. Vitamin B6, depression, and oral contraception. Letter. Lancet ii:516-17, 1974. 25. Benton D, Haller J, Fordy J. Vitamin supplementation for 1 year improves mood. Neuropsychobiology 32(2):98-105, 1995. 26. Hallert C, Astrom J, Walan A. Reversal of psychopathology in adult coeliac disease with the aid of pyridoxine (vitamin B6). Scand J Gastroenterol 18(2):299-304, 1983. 27. Yaryura-Tobias JA. Presentation to the Third World Congress of Biological Psychiatry, Stockholm – reported in Clinical Psychiatrty News. September, 1981. 28. Yaryura-Tobias JA, Bhagavan HN. L-tryptophan in obsessive-compulsive disorders. Am J Psychiatry 134(11):1298-9, 1977. 29. Mira M, Stewart PM, Abraham SF. Vitamin and trace element status in premenstrual syndrome. Am J Clin Nutr 47(4):636-41, 1988. 30. Gallant MP, Bowering J, Short SH, et al. Pyridoxine and magnesium status in women with premenstrual syndrome. Nutr Res 7:243-52, 1987. 31. Stewart A. Clinical and biochemical effects of nutritional supplementation on the premenstrual syndrome. J Reprod Med 32(6):435-41, 1987. 32. Richie CD, Singkamani R. Plasma pyridoxal-5’-phosphate in women with the premenstrual syndrome. Hum Nutr Clin Nutr 40C:75-80, 1986. 33. Parry GJ, Bredesen DE. Sensory neuropathy with low-dose pyridoxine. Neurology 35:1466-8, 1985; Waterston JA, Gilligan BS. Pyridoxine neuropathy. Med J Aust 146:640-2, 1987. 34. Guy Abraham – personal communication reported in Piesse JW. Nutrition factors in the premenstrual syndrome: A review. Int Clin Nutr Rev 4(2):54-81, 1984. 35. Abraham GE. Nutrition and the premenstrual tension syndromes. J Appl Nutr 36(2):103-17, 1985; Hargrove JT, Abraham GT. Effect of vitamin B6 on infertility in women with the premenstrual syndrome. Infertility 2:315: 1979. 36. Leklem JE. Vitamin B6: The pill, pregnancy and premenstrual syndrome. Abstract. J Am Coll Nutr. 11(5):624, 1992. 37. Kleijnen J, Ter Riet G, Knipschild P. Vitamin B6 in the treatment of premenstrual syndrome – a review. Br J Obstet Gynaecol 97(9):847-52, 1990. Berman MK et al. Vitamin B-6 in premenstrual syndrome. J Am Diet Assoc 90(6):859-61, 1990. 38. Doll H, Brown S, Thurston A, Vessey M. Pyridoxine (vitamin B6) and the premenstrual syndrome: A randomized crossover trial. J R Coll Gen Pract 39:364-8, 1989. 39. Brush MG, Bennett T, Hansen K. Pyridoxine in the treatment of premenstrual syndrome: A retrospective survey in 630 patients. Br J Clin Pract 42(11):448-52, 1988. 40. Kendall KE, Schnurr PP. The effects of vitamin B6 supplementation on premenstrual symptoms. Obstet Gynecol 70(2):145-9, 1987. 41. David R. Rubinow, biological psychiatry branch, National Institute of Mental Health (USA) – quoted by Clin Psychiatry News, December, 1987. 42. Hagen I et al. No effect of vitamin B-6 against premenstrual tension: A controlled clinical study. Acta Obstet Gynecol Scand 64:667, 1985. 43. Williams MJ, Harris RI, Dean BC. Controlled trial of pyridoxine in the premenstrual syndrome. J Int Med Res 13:174-9, 1985. 44. Barr W. Pyridoxine supplements in the premenstrual syndrome. Practitioner 228:425-7, 1984. 45. Mattes JA, Martin D. Pyridoxine in premenstrual depression. Hum Nutr Appl Nutr 36(2):131-3, 1982. 46. Abraham GE, Hargrove JT. Effect of vitamin B-6 on premenstrual symptomatology in women with premenstrual tension syndrome: A double-blind crossover study. Infertility 3:155-65, 1980. 47. Day JB. Clinical trials in the premenstrual syndrome. Curr Med Res Opin (Suppl 6) 5:40-5, 1979. 48. Kerr GD. The management of the premenstrual syndrome. Curr Med Res Opin (Suppl 4) 4:29-34, 1977. 49. Stokes J, Mendels J. Pyridoxine and premenstrual tension. Letter. Lancet i:1177-8, 1972. 50. Piesse JW. Nutrition factors in the premenstrual syndrome. Int Clin Nutr Rev 4(2):54-81, 1984. 51. Lee CM, Leklem JE. Blood magnesium constancy with vitamin B-6 supplementation in pre- and post-menopausal women. Ann Clin Lab Sci 14(2):151-4, 1984. 52. Abraham GE et al. Effect of vitamin B6 on plasma and red blood cell magnesium levels in premenopausal women. Ann Clin Lab Sci 11(4):333-6, 1981. 53. Holley J et al. Effect of vitamin B6 nutritional status on the uptake of [3H]-oestradiol into the uterus, liver and hypothalamus of the rat. J Steroid Biochem 18:161-6, 1983. 54. Pfeiffer CC, Audette L. Pyroluria – Zinc and B6 deficiencies. Int Clin Nutr Rev 8(3):107-10; 1988. 55. Pfeiffer CC. The schizophrenias ’76. Biol Psychiatry 2:773-5, 1976. 56. Pfeiffer CC, Bacchi D. Copper, zinc, manganese, niacin and pyridoxine in the schizophrenias. J Appl Nutr 27:9-39, 1975. 57. Pfeiffer CC. Observations on trace and toxic elements in hair and serum. J Orthomol Psychiatry 3(4):259-64, 1974. 58. Cruz R, Vogel WH. Pyroluria: A poor marker in chronic schizophrenia. Am J Psychiatry 135(10):1239-40, 1978. 59. Parry GJ. Sensory neuropathy with low-dose pyridoxine. Neurology 35:1466:8, 1985. 60. Kleijnen J, Knipschild P. Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans. Biol Psychiatry 29(9):931-41, 1991. 61. Brooks SC et al. An unusual schizophrenic illness responsive to pyridoxine HCl (B6) subsequent to phenothiazine and butyrophenone toxicities. Biol Psychiatry 18(11):1321-8, 1983. 62. Yamauchi M. Effects of L-dopa and vitamin B6 on electroencephalograms of schizophrenic patients: A preliminary report. Folia Psychiatrica et Neurologica Japonica 30(2):121-51, 1976. 63. Sandyk R, Pardeshi R. Pyridoxine improves drug-induced parkinsonism and psychosis in a schizophrenic patients. J Neurosci 53(3-4):225-32, 1990. 64. Petrie WM, Ban TA, Anath JV. The use of nicotinic acid and pyridoxine in the treatment of schizophrenia. Int Pharmacopsychiatry 16(4):245-50, 1981. 65. Ananth JV, Ban TA, Lehmann HE. Potentiation of therapeutic effects of nicotinic acid by pyridoxine in chronic schizophrenics. Can Psychiatr Assoc J 18:377-83, 1973.

Common Treatments: Inositol

	Inositol, an 'unofficial' B-vitamin, is a cyclic 6-carbon compound quite similar to glucose. In animal cells, it occurs as a component of phospholipids and it stored predominantly in the brain, spinal cord nerves, cerebral spinal fluid, skeletal muscle, and heart muscle. The human body contains more inositol than any other vitamin except niacin. Source Inositol is available from both plant and animal sources. The plant form in which inositol is available is phytic acid, which can bind with minerals and so affect their absorption negatively. The action of the intestinal bacteria liberates inositol from phytic acid, which is found in citrus fruits, nuts, seeds and legumes, wheat germ, brewers yeast, bananas, liver, beef brains and heart, whole grains such as brown rice, oat flakes, unrefined molasses, raisins and vegetables such as cabbage. Function; Reasons For Use Inositol is simply a hexane molecule (ringed structure of 6 carbons) with 6 hydroxyl groups (OH) attached. Inositol is used by the body to complete the synthesis of certain phospholipids, important components of every cell membrane. Inositol is also used to make Inositol Triphosphate (IP3), an important secondary messenger in various cell signaling events. Inositol is also lipotropic, meaning it associates with lipids (fats). Its lipotropic characteristics have been used to help move fatty material from the liver, into the intestines where they can be effectively removed with fiber. Inositol works closely with choline as one of the primary components of the cell membrane. It is also needed for growth and survival of cells in bone marrow, eye membranes, and the intestines. Inositol appears to be a precursor of the phosphoinosities (compounds that may be important in hormonal action) especially in the brain. Proper action of several brain neurotransmitters, such as acetylcholine and serotonin, require inositol. Inositol encourages hair growth and can help prevent baldness. Like choline, inositol helps to move fat out of the liver, and helps prevent serious liver disorders, as well as disorders involving high cholesterol. Serotonin and acetylcholine, two neurotransmitters, both depend upon inositol, and supplementation can therefore assist in the reduction of depression and panic attacks. A reduction in brain inositol levels may induce depression as evidenced by low inositol levels in the cerebrospinal fluid of patients with depression. In a 1-month, double-blind, placebo-controlled study of 28 patients with depression, inositol demonstrated therapeutic results similar to tricyclic antidepressants without the side-effects. Additional studies have revealed that inositol supplementation is an effective treatment in panic and obsessive compulsive disorders. Loss of inositol from nerve cells is the primary reason for diabetic neuropathy, so inositol supplementation can assist in improving this condition. Phytic acid, the plant source of inositol, has been shown to have anticancer properties, which may be one reason why a high-fiber diet protects against many cancers. Inositol also has a prominent calming effect on the central nervous system, so it may be helpful to those with insomnia. Studies on brain waves have shown that it has an effect similar to that of librium or valium. It can gradually lower blood pressure, and can be helpful in cases of schizophrenia, hypoglycemia, and those with high serum copper and low serum zinc levels. Because it stimulates muscles of the alimentary canal, inositol is helpful in cases of constipation. It can also induce labor contractions in pregnant women. Intake of caffeine is known to deplete the bodies supply of inositol. Directions The RDA is 100mg per day, but be aware that this dosage is the minimum that you require to ward off deficiency of this particular nutrient. In the therapeutic use of this nutrient, the dosage is usually increased considerably, but the toxicity level must be kept in mind. It is best used with choline, which should be taken in the same amount as inositol. It is best to take the entire B-group vitamins with it. Vitamin E, vitamin C as well as folic acid and linoleic acid are thought to increase the functioning of inositol. Side-Effects Although no toxic effects are known, diarrhea has been noted with the intake of very high dosage.

B6 and phenols. Finally, an explanation!

Enzyme Stuff discussion on excessive B vitamins

Sometimes parents are advised to give very excessively high doses of B6 for their children with autism spectrum conditions. However, experience shows that many children have very terrible reactions to supplements with excessively high doses of B6. The ARI information from over several decades also shows that the majority of people with autism do not benefit from high B6 vitamin supplements although some do. A high does is about 50 mg, a very high dose 100 mg, and excessively high often way over that. While some B6 as well as other basic vitamins are beneficial, excessive amounts may be too much neuro- stimulant particularly for neurologically sensitive people. It is important to check with a qualified medical doctor for your situation when taking anything over the Recommended Daily Allowance of anything.

Why so many negative reactions and why might some do okay with it? For one thing, most all sources agree that B vitamins work as a team together and should be taken in the proper ratios - a balance of B vitamins. Taking an excessive amount of just one or two individual vitamins in the B family can cause deficiencies in other B vitamins. So you might just be trading one problem for another.

Another problem is that many synthetically made B6 vitamins may be made from coal-tar. Coal-tar derived synthetics include artificial colorings and flavorings. So if someone has a sulfate processing problem, or is sensitive to artificial additives of this nature, or doesn't tolerate phenolic compounds or artificial additives, then they may very likely not tolerate B6 vitamins if they are synthetically derived. If you are not tolerating B vitamins, you might want to look at a non- synthetic source of nutrients. More information and several non-synthetic formulations are at the link below. In the middle of this page are some links that go to research showing why taking lots of synthetic supplements is not always the most healthful, and you might want to try getting as much nutrition from natural sources as possible. Nutrition and enzymes (general diet strategies)

B vitamins and phenol reactions

Biochem Pharmacol 1994 Jun 1;47(11):2087-95

Inhibition of phenol sulfotransferase by pyridoxal phosphate.

Bartzatt R, Beckmann JD.

Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-5300.

The biologically abundant cofactor, pyridoxal-5-phosphate (PLP), is a potent inhibitor of bovine phenol (aryl) sulfotransferase (PST). Preincubation of purified enzyme with as little as 1 microM PLP decreased PST activity by 50%. Excess 2-naphthol protected PST from inactivation by PLP, whereas 2-naphthyl sulfate and PAPS were not protective. Although PLP inhibition was apparently competitive with 2-naphthol, a steady-state kinetic Ki value could not be measured due to non-linear Lineweaver-Burk plots in the presence of the inhibitor. Kinetic progress curves revealed that this was due to progressive loss of activity during catalysis. The kinetics of inactivation of PST by PLP were pseudo-first-order and exhibited saturation. The derived KI value for the binding of PLP to PST in the initial reversible step was 23 microM, with a maximal rate of inactivation of 0.077 min(-1). Absorbance spectra of the PST/PLP complex indicated the formation of a Schiff base conjugate, and this is consistent with decreased electrophoretic mobility of the protein-PLP adduct in the presence of dodecyl sulfate only after reduction with borohydride. These results point to the possible regulation of an important detoxification enzyme by a ubiquitous cofactor.

Glutamate "Blockers?"

Article that asks what things might be taken to block excess glutamates

Mike: Here's a practical question that's actually been burning in my head for about eight years: Is there anything that a person can take to block the absorption of MSG or glutamate as a defensive supplement?

Dr. Blaylock: Well, not necessarily to block it. You have other amino acids that can't compete for glutamic acid absorption. So that may be one way to help reduce the rate at which it would be absorbed.

Mike: Which aminos would those be?

Dr. Blaylock: Those would include leucine, isoleucine and lysine. They would compete for the same carrier system, so that would slow down absorption. There are a lot of things that act as glutamate blockers. You know, like silimarin, curcumin and ginkgo biloba. These things are known to directly block glutamate receptors and reduce excitotoxicity. Curcumin is very potent. Most of your flavonoids.

Magnesium is particularly important, because magnesium can block the MNDA glutamate type receptor. That's its natural function, so it significantly reduces toxicity. Vitamin E succinate is powerful at inhibiting excitotoxicity, as are all of your antioxidants. They found combinations of B vitamins also block excitotoxicity.